Anti-CEACAM6 Antibody, Mouse Monoclonal
Cat: 10823-MM06
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Anti-CEACAM6 Antibody, Mouse Monoclonal の製品情報
製品名
Anti-CEACAM6 Antibody, Mouse Monoclonal
検証済のアプリケーション
ELISA
交差反応
Reacts with: Human
特異性
Human CEACAM6
免疫原
Recombinant Human CD66c protein (Catalog#10823-H08H)
調製
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CEACAM6 / CD66c (rhCEACAM6; Catalog#10823-H08H; NP_002474.4; Met 1-Gly 320). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
ソース
Monoclonal Mouse IgG1 Clone #8B7G4
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-CEACAM6 Antibody, Mouse Monoclonal 検証済のアプリケーション
| アプリケーション | 推奨希釈率/用量 |
|---|---|
| ELISA | 1:1000-1:2000 |
Please Note: Optimal concentrations/dilutions should be determined by the end user.
Anti-CEACAM6 Antibody, Mouse Monoclonal: 別名
Anti-CD66c Antibody; Anti-CEA Antibody; Anti-CEAL Antibody; Anti-NCA Antibody
CEACAM6 背景情報
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.
完全な名称
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
参考文献
- Duxbury MS, et al. (2004) Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene. 23(34): 5834-42.
- Lewis-Wambi JS, et al. (2008) Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer. 44(12): 1770-9.
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