Recombinant Anti-Her2/ERBB2 Antibody (PE), Rabbit Monoclonal

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Recombinant Anti-Her2/ERBB2 Antibody (PE), Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-Her2/ERBB2 Antibody (PE), Rabbit Monoclonal
検証済のアプリケーション
FCM
交差反応
Reacts with: Mouse
特異性
Mouse Her2/ERBB2
免疫原
Recombinant Mouse HER2 / ErbB2 / CD340 Protein (Catalog#50714-M08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse HER2 / ErbB2 / CD340 (rM HER2 / ErbB2 / CD340; Catalog#50714-M08H; P70424; Met1-Thr653) and conjugated with PE under optimum conditions, the unreacted PE was removed.
ソース
Monoclonal Rabbit IgG Clone #001
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
標識物
PE
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Recombinant Anti-Her2/ERBB2 Antibody (PE), Rabbit Monoclonal の画像

Flow cytometric analysis of Mouse Her2/ERBB2 expression on 3T3-L1 cells. Cells were stained with PE-conjugated anti-Mouse Her2/ERBB2 . The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Recombinant Anti-Her2/ERBB2 Antibody (PE), Rabbit Monoclonal: 別名

Anti-c-erbB2 Antibody; Anti-c-neu Antibody; Anti-Erbb-2 Antibody; Anti-HER-2 Antibody; Anti-HER2 Antibody; Anti-l11Jus8 Antibody; Anti-mKIAA3023 Antibody; Anti-Neu Antibody

Her2/ERBB2 背景情報

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
完全な名称
erb-b2 receptor tyrosine kinase 2
参考文献
  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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