Recombinant Mouse HER2 / ErbB2 / CD340 Protein (Catalog#50714-M08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse HER2 / ErbB2 / CD340 (rM HER2 / ErbB2 / CD340; Catalog#50714-M08H; P70424; Met1-Thr653) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Monoclonal Rabbit IgG Clone #001
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
10 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !
Flow cytometric analysis of Mouse Her2/ERBB2 expression on 3T3-L1 cells. Cells were stained with PE-conjugated anti-Mouse Her2/ERBB2 . The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.