Anti-Fractalkine Antibody, Rabbit Polyclonal

Anti-Fractalkine Antibody, Rabbit Polyclonal の製品情報

Anti-Fractalkine Antibody, Rabbit Polyclonal
Reacts with: Human
Human Fractalkine
E. coli-derived Human Fractalkine / CX3CL1 fragment
Produced in rabbits immunized with E. coli-derived Human Fractalkine / CX3CL1 fragment, and purified by antigen affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
PBS, pH7.0 with 0.03% Proclin300
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Anti-Fractalkine Antibody, Rabbit Polyclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
IHC-P 1:200-1:1000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Fractalkine Antibody, Rabbit Polyclonal の画像

Immunochemical staining of human CX3CL1 in human kidney with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
Immunochemical staining of human CX3CL1 in human skeletal muscle with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.

Anti-Fractalkine Antibody, Rabbit Polyclonal: 別名

Anti-ABCD-3 Antibody; Anti-C3Xkine Antibody; Anti-CXC3 Antibody; Anti-CXC3C Antibody; Anti-fractalkine Antibody; Anti-neurotactin Antibody; Anti-NTN Antibody; Anti-NTT Antibody; Anti-SCYD1 Antibody

Fractalkine 背景情報

Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.
chemokine (C-X3-C motif) ligand 1
  • Imai T, et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 91(4): 521-30.
  • Papadopoulos EJ, et al. (1999) Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol. 29 (8): 2551-9.
  • Umehara H, et al. (2004) Fractalkine in vascular biology: from basic research to clinical disease". Arterioscler. Thromb Vasc Biol. 24 (1): 34-40.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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