Recombinant Anti-CD137 Antibody (PE), Rabbit Monoclonal

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Recombinant Anti-CD137 Antibody (PE), Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-CD137 Antibody (PE), Rabbit Monoclonal
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human CD137
免疫原
Recombinant Human CD137 Protein (Catalog#10041-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD137 (rh CD137; Catalog#10041-H08H; NP_001552.2; Met1-Gln186) and conjugated with PE under optimum conditions, the unreacted PE was removed.
ソース
Monoclonal Rabbit IgG Clone #819
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
標識物
PE
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Recombinant Anti-CD137 Antibody (PE), Rabbit Monoclonal の画像

Flow cytometric analysis of Human CD137 expression on human whole blood lymphocytes. Cells were stained with PE-conjugated anti-Human CD137. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

Recombinant Anti-CD137 Antibody (PE), Rabbit Monoclonal: 別名

Anti-4-1BB Antibody; Anti-CD137 Antibody; Anti-CDw137 Antibody; Anti-ILA Antibody

CD137 背景情報

CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion.
完全な名称
tumor necrosis factor receptor superfamily, member 9
研究分野
参考文献
  • Sica G, et al. (1999) Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy. Arch Immunol Ther Exp (Warsz). 47(5): 275-9.
  • Nam KO, et al. (2005) The therapeutic potential of 4-1BB (CD137) in cancer. Curr Cancer Drug Targets. 5(5): 357-63.
  • Wang Q, et al. (2008) Analysis of CD137 and CD137L expression in human primary tumor tissues. Croat Med J. 49(2): 192-200.
  • Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90.
  • Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.

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