Recombinant Anti-TIM-1/KIM-1 Antibody, Rabbit Monoclonal

RRID Number: AB_2860539
EliteRmab®, manufactured by recombinant technology

Recombinant Anti-TIM-1/KIM-1 Antibody, Rabbit Monoclonal の製品情報

製品名
Recombinant Anti-TIM-1/KIM-1 Antibody, Rabbit Monoclonal
検証済のアプリケーション
ELISA,IHC-P
交差反応
Reacts with: Canine
特異性
Canine TIM-1/KIM-1
免疫原
Recombinant Canine HAVCR1 protein (Catalog#70001-D07H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Canine HAVCR1 extracellular domain (rCanine TIMD-1 / HAVCR1; Catalog#70001-D07H; XP_854888.1; Tyr 21-Ser 160).
ソース
Monoclonal Rabbit IgG Clone #202
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Recombinant Anti-TIM-1/KIM-1 Antibody, Rabbit Monoclonal 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
IHC-P 1:1000-1:4000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Recombinant Anti-TIM-1/KIM-1 Antibody, Rabbit Monoclonal の画像

Immunochemical staining of Canine KIM1 in canine kidney with rabbit monoclonal antibody (1:2000, formalin-fixed paraffin embedded sections).

TIM-1/KIM-1 背景情報

HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulin mucin 1 (TIM-1), is a type of integral membrane glycoprotein. KIM-1 protein is widely expressed with the highest levels in the kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy, and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
完全な名称
hepatitis A virus cellular receptor 1
参考文献
  • Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
  • Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
  • Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.
  • Novel genomic biomarkers for acute gentamicin nephrotoxicity in dog
    Author
    JE McDuffie, J Gao, J Ma, D La, A Bittner…
    Year
    2013
    Journal
    Open Journal of Molecular and Integrative Physiology

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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