Anti-Beta-2 microglobulin Antibody (FITC)

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Anti-Beta-2 microglobulin Antibody (FITC) (Mouse Monoclonal 抗体) の製品情報

製品名
Anti-Beta-2 microglobulin Antibody (FITC)
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human Beta-2 microglobulin
免疫原
Recombinant Human Beta-2 microglobulin/B2M Protein (Catalog#11976-H08H)
調製
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Beta-2 microglobulin/B2M (rh Beta-2 microglobulin/B2M; Catalog#11976-H08H; NP_004039.1; Met1-Met119) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
ソース
Monoclonal Mouse IgG1 Clone #34
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
標識物
FITC
濃度
5 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-Beta-2 microglobulin Antibody (FITC) (Mouse Monoclonal 抗体) の画像

Flow cytometric analysis of Human B2M / Beta-2-microglobulin expression on human whole blood lymphocytes. Cells were stained with FITC-conjugated anti-Human B2M / Beta-2-microglobulin. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

Anti-Beta-2 microglobulin Antibody (FITC): 別名

Anti-Beta-2 microglobulin Antibody

Beta-2 microglobulin 背景情報

B2M, also known as β2-Microglobulin or CDABP92, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.
完全な名称
beta-2 microglobulin
参考文献
  • Poulik MD, et al. (1979) Beta 2-Microglobulin: methods and clinical applications. CRC Ctit Rev Clin Lab Sci. 10(3): 225-45.
  • Poulik MD, et al. (1975) Beta2-Microglobulins. Contemp Top Mol Immunol. 4: 157-204.
  • Berggard I. (1976) Beta2-Microglobulins: isolation, properties, and distribution. Fed Proc. 35(5): 1167-70.

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