FGF1 Protein, Human, Recombinant

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FGF1 Protein, Human, Recombinant: 製品情報

純度
> 95 % as determined by SDS-PAGE
内毒素
Please contact us for more information.
活性
Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 50-200 pg/ml.
タンパク質の構築
A DNA sequence encoding the mature form of human FGF acidic (AAA79245.1) (Phe 16-Asp 155) was expressed, with an additional Met at the N-terminus.
GenBank No.
発現ホスト
E. coli
Human
予測N末端
Met 1
分子量
The recombinant human FGF acidic consists of 141 amino acids and has a calculated molecular mass of 16 kDa as estimated by SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

FGF1 Protein, Human, Recombinant: 画像

FGF1 Protein, Human, Recombinant: 別名

AFGF Protein, Human; ECGF Protein, Human; ECGF-beta Protein, Human; ECGFA Protein, Human; ECGFB Protein, Human; FGF-1 Protein, Human; FGF-alpha Protein, Human; FGFA Protein, Human; GLIO703 Protein, Human; HBGF-1 Protein, Human; HBGF1 Protein, Human

FGF1 背景情報

aFGF, also known as FGF1 and HBGF-1, is a member of the fibroblast growth factor family. The biological activity of aFGF protein is exerted through binding to four high affinity cell surface receptors (FGFR1–4), which results in receptor dimerization and transphosphorylation in the tyrosine kinase domain. aFGF protein shows a wide range of endocrine-like activities. As a multiple function growth factor, this protein is involved in embryo development and tissue repair. Additionally, this protein is considered to function in several important physiological and pathological processes, such as embryonic development, morphogenesis, angiogenesis, wound healing and atheromatosis, carcinogenesis, development, and invasion of cancer.

References

完全な名称
fibroblast growth factor 1 (acidic)
参考文献
  • Jaye M., et al.,(1986), Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization. Science 233:541-545.
  • Mergia A., et al., (1989), Structural analysis of the gene for human acidic fibroblast growth factor.Biochem. Biophys. Res. Commun. 164:1121-1129.
  • Wang W.P., et al.,(1989), Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.Mol. Cell. Biol. 9:2387-2395.
  • miR-21 promotes the differentiation of hair follicle-derived neural crest stem cells into Schwann cells
    Author
    Ni, Y;Zhang, K;Liu, X;Yang, T;Wang, B;Fu, L;
    Year
    2014
    Journal
    Neural Regeneration Research
    Application
    the cuture of neural crest stem cells; the induction of hair follicle-derived neural crest stem cells differentied into Schwann cells
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