TRXR1 / TXNRD1 Protein, Human, Recombinant (aa 161-647, His Tag)

1/1
Price:
Size:
Number:

TRXR1 / TXNRD1 Protein, Human, Recombinant (aa 161-647, His Tag): 製品情報

純度
> 90 % as determined by SDS-PAGE
内毒素
Please contact us for more information.
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the human TXNRD1 isoform 1 (Q16881-1) (Tyr 161-Cys 647) was expressed, with a polyhistide tag at the N-terminus.
NCBI Reference No.
発現ホスト
E. coli
Human
予測N末端
Met
分子量
The recombinant human TXNRD1 consisting of 498 amino acids and has a calculated molecular mass of 55 kDa. It migrates as an 60 kDa band in SDS-PAGE under reducing conditions as predicted.
バッファー
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

TRXR1 / TXNRD1 Protein, Human, Recombinant (aa 161-647, His Tag): 画像

TRXR1 / TXNRD1 Protein, Human, Recombinant (aa 161-647, His Tag): 別名

GRIM-12 Protein, Human; TR Protein, Human; TR1 Protein, Human; TRXR1 Protein, Human; TXNR Protein, Human

TRXR1 / TXNRD1 背景情報

Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.
完全な名称
thioredoxin reductase 1
参考文献
  • Gasdaska P.Y., et al., 1995, FEBS Lett. 373:5-9.
  • Rundloef A.-K., et al., 2004, Free Radic. Biol. Med. 36:641-656.
  • Rikova K., et al., 2007, Cell 131:1190-1203.
  • Fritz-Wolf K., et al., 2007, J. Mol. Biol. 370:116-127.
  • Choudhary C., et al., 2009, Science 325:834-840.
カートに追加しました カートに追加しませんでした カートを更新しています。少々お待ちください