TSPAN8 cDNA ORF Clone, Human, untagged

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TSPAN8 cDNA ORF Clone, Human, untagged: 製品情報

遺伝子
Human
NCBI 参考シーケンス番号
遺伝子の長さ
714 bp
製品の特徴
Full length Clone DNA of Human tetraspanin 8
プラスミド
プロモーター
Enhanced CMV mammalian cell promoter
ベクター
シークエンシングプライマー
T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
品質管理
The plasmid is confirmed by full-length sequencing.
スクリーニング
細菌スクリーニング抵抗力
Ampicillin
細胞スクリーニング抵抗力
Hygromycin
アプリケーション
Stable or Transient mammalian expression
保存 & 配送
配送方法
Each tube contains lyophilized plasmid.
保存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

TSPAN8 cDNA ORF Clone, Human, untagged: 別名

CO-029 cDNA ORF Clone, Human; TM4SF3 cDNA ORF Clone, Human

TSPAN8 背景情報

Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a negative regulator of Tspan8 expression. p53 as a regulator of melanoma invasion and the concept that reactivating p53 could provide a strategy for modulating not only proliferative but also invasive capacity in melanoma treatment. Tetraspanin 8 (TSPAN8) is a tumor-associated antigen implicated in tumor progression and metastasis. TSPAN8 may play an important role in mCRC cell invasion. TSPAN8 was overexpressed in human gastric cancer tissues and gastric cancer cell lines compared with the normal. TSPAN8 overexpression promoted cell proliferation and invasion, while TSPAN8 suppression inhibited cell proliferation and invasion. TSPAN8 could activate the ERK MAPK pathway in gastric cancer cells, and MEK-ERK inhibition reversed the effects of TSPAN8 overexpression on cell proliferation and invasion.
完全な名称
tetraspanin 8
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