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Serum amyloid P component 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

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    人々 APCS 抗体製品情報
    免疫原:Recombinant Human Serum amyloid P component Protein (Catalog#13610-H08H)
    Clone ID:
    Ig タイプ:Rabbit IgG
    濃度:
    エンドトキシン:
    製剤:0.2 μm filtered solution in PBS
    調製:Produced in rabbits immunized with purified, recombinant Human Serum amyloid P component (rh Serum amyloid P component; Catalog#13610-H08H; P02743; Met1-Val223). Serum amyloid P component specific IgG was purified by Human Serum amyloid P component affinity chromatography.
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    Serum amyloid P component 背景

    Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.

    人々 Serum amyloid P component 参考文献
  • Wang Y, et al. (2011) Human serum amyloid P functions as a negative regulator of the innate and adaptive immune responses to DNA vaccines. J Immunol. 186(5): 2860-70.
  • Hawkins PN. (2002) Serum amyloid P component scintigraphy for diagnosis and monitoring amyloidosis. Curr Opin Nephrol Hypertens. 11(6): 649-55.
  • Noursadeghi M, et al. (2000) Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen. Proc Natl Acad Sci U S A. 97: 14584-9.
  • de Haas CJ. (1999) New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein. FEMS Immunol Med Microbiol. 26(3-4): 197-202.
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    カタログ: 13610-T16-50
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