SLAMF8 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All SLAMF8 reagents are produced in house and quality controlled, including 6 SLAMF8 Antibody, 26 SLAMF8 Gene, 1 SLAMF8 Lysate, 1 SLAMF8 Protein, 2 SLAMF8 qPCR. All SLAMF8 reagents are ready to use.

SLAMF8 Protein (1)

    SLAMF8 Antibody (6)

      SLAMF8 cDNA Clone (26)

      NM_020125.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_029084.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      SLAMF8 Lysate (1)

        SLAMF8 の背景知識

        The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. SLAM family of receptors is expressed by a wide range of immune cells. Through their cytoplasmic domain, SLAM family receptors associate with SLAM-associated protein (SAP)-related molecules, a group of cytoplasmic adaptors composed almost exclusively of an SRC homology 2 domain. SLAM family receptors, in association with SAP family adaptors, have crucial roles during normal immune reactions in innate and adaptive immune cells.
        Mouse SLAM family member 8, also known as B-lymphocyte activator macrophage expressed, BCM-like membrane protein, SLAMF8 and BLAME, is a single-pass type I membrane protein. It contains oneIg-like C2-type (immunoglobulin-like) domain. SLAMF8 / BLAME is expressed in lymph node, spleen, thymus and bone marrow. It may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.

        SLAMF8 の参考文献

        • Kingsbury G.A., et al., 2001, J. Immunol. 166:5675-80.
        • Zhang Z., et al., 2004, Protein Sci. 13: 2819-24.
        • Veillette,A. et al., 2006, Nat Rev Immunol  6 (1): 56-66.
        • Veillette,A. et al., 2006, Trends Immunol  27 (5): 228-34.
        • Yan,Q. et al., 2007, Proc Natl Acad Sci. USA.104 (25):10583-8.

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