SAP / SH2D1A Protein, Human, Recombinant (His Tag)

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SAP / SH2D1A Protein, Human, Recombinant (His Tag): 製品情報

純度
> 94 % as determined by SDS-PAGE
内毒素
Please contact us for more information.
活性
1. Measured by its ability to bind recombinant human SLAMF1 in a functional ELISA.
2. Measured by its ability to bind recombinant human SLAMF6 in a functional ELISA.
3. Measured by its ability to bind recombinant mouse SLAMF6 in a functional ELISA.
4. Measured by its ability to bind recombinant mouse CD84 in a functional ELISA.
タンパク質の構築
A DNA sequence encoding the human SH2D1A isoform 1 (NP_002342.1) (Pro 2-Lys 97) was expressed, with a polyhistidine tag at the N-terminus.
NP No.
発現ホスト
E. coli
Human
予測N末端
Met
分子量
The recombinant human SH2D1A consisting of 139 amino acids and has a calculated molecular mass of 15.6 kDa.It migrates as an approximately 14 kDa band in SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile PBS, pH 7.5, 20% glycerol
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

SAP / SH2D1A Protein, Human, Recombinant (His Tag): 画像

SAP / SH2D1A Protein, Human, Recombinant (His Tag): 別名

DSHP Protein, Human; EBVS Protein, Human; IMD5 Protein, Human; LYP Protein, Human; MTCP1 Protein, Human; SAP Protein, Human; SAP/SH2D1A Protein, Human; XLP Protein, Human; XLPD Protein, Human; XLPD1 Protein, Human

SAP / SH2D1A 背景情報

SH2 domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD15 / SLAM, CD84, CD229 / Ly-9, and CD244 / 2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome.
完全な名称
SH2 domain containing 1A
参考文献
  • Morra M, et al. (2005) Defective B cell responses in the absence of SH2D1A. PNAS. 102 (13): 4819-23.
  • Morra M, et al. (2001) Characterization of SH2D1A Missense Mutations Identified in X-linked Lymphoproliferative Disease Patients. The Journal of Biological Chemistry. 276: 36809-16.
  • Hron JD, et al. (2004) SH2D1A Regulates T-dependent Humoral Autoimmunity. JEM. 200 (2): 261-6.
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