S100A4 Protein, Human, Recombinant (Fc Tag)

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S100A4 Protein, Human, Recombinant (Fc Tag): 製品情報

純度
> 95 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the human S100A4 (NP_002952.1) (Met 1-Lys 101) was expressed with the fused Fc region of human IgG1 at the N-terminus.
NP No.
発現ホスト
HEK293 Cells
Human
予測N末端
Glu 20
分子量
The recombinant human Fc/S100A4 is a disulfide-linked homodimeric protein. The reduced monomer consists of 338 amino acids and has a predicted molecular mass of 38.4 kDa. As a result of glycosylation, the apparent molecular mass of rhFc/S100A4 monomer is approximately 40 kDa in SDS-PAGE under reducing conditions.
バッファー
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

S100A4 Protein, Human, Recombinant (Fc Tag): 画像

S100A4 Protein, Human, Recombinant (Fc Tag): 別名

18A2 Protein, Human; 42A Protein, Human; CAPL Protein, Human; FSP1 Protein, Human; MTS1 Protein, Human; P9KA Protein, Human; PEL98 Protein, Human

S100A4 背景情報

S1A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S1 proteins containing two EF-hand calcium-binding motifs. In humans at least 2 S1 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S1A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S1A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S1A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.
完全な名称
S100 calcium binding protein A4
参考文献
  • Ambartsumian N. et al., 1995, Gene. 159: 125-30.
  • Marenholz I. et al., 2004, Biochem Biophys Res Commun. 322: 1111-22.
  • Helfman DM. et al., 2005, Br J Cancer. 92: 1955-8.
  • Saleem M. et al., 2006, Proc Natl Acad Sci. 103: 14825-30.
  • Boye K. et al., 2008, Int J Cancer. 123: 1301-10.
  • Garrett SC. et al., 2006, J Biol Chem. 281: 677-80.
  • Kriajevska M. et al., 2002, J Biol Chem. 277: 5299-335.
  • S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells
    Author
    Zhang, J;Jiao, Y;Hou, S;Tian, T;Yuan, Q;Hao, H;Wu, Z;Bao, X;
    Year
    2017
    Journal
    Sci Rep
    Application
    cell-based(stimulate)
  • S100A4 promotes lung tumor development through β-catenin pathway-mediated autophagy inhibition
    Author
    Hou, S;Tian, T;Qi, D;Sun, K;Yuan, Q;Wang, Z;Qin, Z;Wu, Z;Chen, Z;Zhang, J;
    Year
    2018
    Journal
    Cell Death Dis
    Application
    cell-based
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