S100A4 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All S100A4 reagents are produced in house and quality controlled, including 3 S100A4 Antibody, 30 S100A4 Gene, 3 S100A4 Lysate, 5 S100A4 Protein, 2 S100A4 qPCR. All S100A4 reagents are ready to use.

S100A4 Protein (5)

S100A4 Antibody (3)

S100A4 cDNA Clone (30)

NM_002961.2

クローニングベクター cDNA 製品

In lentiviral vector

NM_011311.1

クローニングベクター cDNA 製品

In lentiviral vector

S100A4 Lysate (3)

S100A4 の背景知識

S1A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S1 proteins containing two EF-hand calcium-binding motifs. In humans at least 2 S1 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S1A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S1A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S1A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.

S100A4 の参考文献

  • Ambartsumian N. et al., 1995, Gene. 159: 125-30.
  • Marenholz I. et al., 2004, Biochem Biophys Res Commun. 322: 1111-22.
  • Helfman DM. et al., 2005, Br J Cancer. 92: 1955-8.
  • Saleem M. et al., 2006, Proc Natl Acad Sci. 103: 14825-30.
  • Boye K. et al., 2008, Int J Cancer. 123: 1301-10.
  • Garrett SC. et al., 2006, J Biol Chem. 281: 677-80.
  • Kriajevska M. et al., 2002, J Biol Chem. 277: 5299-335.