RAC2 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All RAC2 reagents are produced in house and quality controlled, including 45 RAC2 Gene, 1 RAC2 Protein, 2 RAC2 qPCR. All RAC2 reagents are ready to use.

RAC2 Protein (1)

    RAC2 cDNA Clone (45)

    NM_002872.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_009008.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001008384.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    RAC2 の背景知識

    Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is attached to the small G-protein, the enzyme is inactivated. Release of the GDP and replace of the GTP cativate the GTPasee. Rac2 remains active until the GTP is hydrolyzed to GDP. Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADPH oxidase complex and shares 92% amino acid identity with the ubiquitously expressed Rac1. The small G-protein Rac2 regulates the rearrangements of actin and membrane necessary for Fcy receptor-mediated phagocytosis by macrophages. Activated Rac2 binds to the p21-binding domain of PAK1 and this binding provided a basis for microscopic methods to localize activation of these G proteins inside cells.

    RAC2 の参考文献

    • Adam D, et al. (2003) Cdc42, Rac1, and Rac2 Display Distinct Patterns of Activation during Phagocytosis.Mol Biol Cell. 15 (8 ): 3509-19.
    • Walmsley MJ, et al. (2003) Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling. Science. 302 (5644): 459-62.
    • Holland M, et al. (2011) RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood. 118 (3): 638-49.

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