Anti-NRG1 Alpha Antibody

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Anti-NRG1 Alpha Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-NRG1 Alpha Antibody
検証済のアプリケーション
WB,ELISA
交差反応
Reacts with: Human
特異性
Human Neuregulin-1
免疫原
Recombinant Human NRG1 Protein (Catalog#13499-H08H)
調製
Produced in rabbits immunized with purified, recombinant Human NRG1 (rh NRG1; Catalog#13499-H08H; Q02297-1; Ser20-Lys241). NRG1 specific IgG was purified by Human NRG1 affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A & Antigen Affinity
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-NRG1 Alpha Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
WB 1:500-1:1000
ELISA 1:25000-1:50000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-NRG1 Alpha Antibody (Rabbit Polyclonal 抗体) の画像

Anti-NRG1 rabbit polyclonal antibody at 1:500 dilution

Lane A: Hela Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:70 kDa

Observed band size:100 kDa

Anti-NRG1 Alpha Antibody: 別名

Anti-ARIA Antibody; Anti-GGF Antibody; Anti-GGF2 Antibody; Anti-HGL Antibody; Anti-HRG Antibody; Anti-HRG1 Antibody; Anti-HRGA Antibody; Anti-MST131 Antibody; Anti-MSTP131 Antibody; Anti-NDF Antibody; Anti-Neuregulin 1 Antibody; Anti-NRG1-IT2 Antibody; Anti-SMDF Antibody

Neuregulin-1 背景情報

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
完全な名称
neuregulin 1
参考文献
  • Nicodemus KK, et al. (2010) Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls. Arch Gen Psychiatry. 67 (10): 991-1001.
  • Tan W, et al. (2007) Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia. J Biol Chem. 282 (33): 24343-51.
  • Holmes WE, et al. (1992) Identification of heregulin, a specific activator of p185erbB2. Science. 256 (5060): 1205-10.
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