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M-CSF / CSF-1 抗体, ウサギモノクローナル抗体

    データシートレビュー関連製品プロトコル
    マウス CSF1 抗体製品情報
    免疫原:Recombinant Mouse M-CSF / CSF-1 protein (Catalog#51112-M08H)
    Clone ID:007
    Ig タイプ:Rabbit IgG
    濃度:
    エンドトキシン:
    製剤:0.2 μm filtered solution in PBS
    調製:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse M-CSF / CSF-1 (rh M-CSF / CSF-1; Catalog#51112-M08H; P07141-1; Met1-Glu262).
    Other CSF1 Antibody Products
    M-CSF/CSF-1 背景

    Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

    マウス M-CSF/CSF-1 参考文献
    1. Pandit J. et al., 1992, Science. 258: 1358-62.
    2. Tokai M. et al., 2000, J Bacteriol. 182 (10): 2865-8.
    3. Fan X. et al., 2001, Am J Physiol Endocrinol Metab. 280 (1): E103-11.
    4. Frangogiannis NG. et al., 2003, Am J Physiol Heart Circ Physiol. 285 (2): H483-92.
    5. Cupp JS. et al., 2007, Am J Surg Pathol. 31 (6): 970-6.
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    カタログ: 51112-R007-50
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    Datasheet & Documentation

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