LRP1 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All LRP1 reagents are produced in house and quality controlled, including 1 LRP1 Antibody, 1 LRP1 qPCR. All LRP1 reagents are ready to use.

LRP1 の背景知識

Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is an endocytic receptor involved in several cellular processes. LRP1 / CD91 is a member of the cluster of differentiation (CD) system. The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. LRP1 / CD91 is involved in endocytosis and in phagocytosis of apoptotic cells and is required for early embryonic development. LRP1 / CD91 is also Involved in cellular lipid homeostasis, the plasma clearance of chylomicron remnants, activated LRPAP1 (alpha 2-macroglobulin), and the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. LRP1 / CD91 May modulate cellular events, such as APP metabolism kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission need the involvement of LRP1 / CD91.

LRP1 の参考文献

  • Su HP, et al. (2002) Interaction of CED-6 / GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91 / low density lipoprotein receptor-related protein (LRP). J Biol Chem. 277(14): 11772-9.
  • Chen JS, et al. (2010) Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91 / LRP-1 and NF-kappaB-mediated integrin alphaV expression. J Biol Chem. 285(33): 25458-66.
  • Dasgupta S, et al. (2008) Factor VIII bypasses CD91 / LRP for endocytosis by dendritic cells leading to T-cell activation. Haematologica. 93(1): 83-9.