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KIRREL1 / NEPH1 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

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    マウス KIRREL 抗体製品情報
    免疫原:Recombinant Mouse KIRREL1 / NEPH1 protein (Catalog#50193-M08H)
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    Ig タイプ:Rabbit IgG
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    エンドトキシン:
    製剤:0.2 μm filtered solution in PBS
    調製:Produced in rabbits immunized with purified, recombinant Mouse KIRREL1 / NEPH1 (rh KIRREL1 / NEPH1; Catalog#50193-M08H; NP_570937.2; Met1-Leu525). KIRREL1 / NEPH1 specific IgG was purified by Mouse KIRREL1 / NEPH1 affinity chromatography.
    Other KIRREL Antibody Products
    KIRREL1/NEPH1 背景

    NEPH1 (KIRREL1) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. All three Neph proteins share a conserved podocin-binding motif; mutation of a centrally located tyrosine residue dramatically lowers the affinity of Neph1 for podocin. Neph1 triggers AP-1 activation similarly to nephrin but requires the presence of Tec family kinases for efficient transactivation. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain and a cytoplasmic tail, which is expressed in slit diaphragm domains of podocytes and in vertebrate and invertebrate nervous systems. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice results in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death.

    マウス KIRREL1/NEPH1 参考文献
  • Sellin L, et al. (2003) NEPH1 defines a novel family of podocin interacting proteins. FASEB J. 17(1): 115-7.
  • Kim EY, et al. (2009) Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes. Am J Physiol Cell Physiol. 297(6): C1379-88.
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    カタログ: 50193-T16-200
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