Anti-TIM-1 / KIM-1 Antibody

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Anti-TIM-1 / KIM-1 Antibody (Mouse Monoclonal 抗体) の製品情報

製品名
Anti-TIM-1 / KIM-1 Antibody
検証済のアプリケーション
ELISA,ELISA(Det)
交差反応
Reacts with: Human
特異性
Human TIM-1 / KIM-1
No cross-reactivity in ELISA with
Mouse KIM1
Human TIMD3
Rat KIM1
Human TIMD4
Human cell lysate (293 cell line)
免疫原
Recombinant Human KIM-1 / TIM1 / HACVR1 protein (Catalog#11051-H07H)
調製
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human KIM-1 / TIM1 / HACVR1 (rh KIM-1 / TIM1 / HACVR1; Catalog#11051-H07H; AAC39862.1; Ser 21-Gly 290). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
ソース
Monoclonal Mouse IgG1 Clone #10B8C11
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TIM-1 / KIM-1 Antibody (Mouse Monoclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:1000-1:2000
ELISA(Det) 1:1000-1:10000
Notes
ELISA(Det): This antibody will detect Human KIM-1 / TIM1 / HACVR1 in ELISA pair set (Catalog: # SEK11051). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 11051-MM06).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TIM-1 / KIM-1 Antibody: 別名

Anti-CD365 Antibody; Anti-HACVR Antibody; Anti-HAVCR Antibody; Anti-HAVCR-1 Antibody; Anti-KIM-1 Antibody; Anti-KIM1 Antibody; Anti-TIM Antibody; Anti-TIM-1 Antibody; Anti-TIM1 Antibody; Anti-TIMD-1 Antibody; Anti-TIMD1 Antibody

TIM-1 / KIM-1 背景情報

HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
完全な名称
hepatitis A virus cellular receptor 1
参考文献
  • Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
  • Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
  • Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.

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