JAM-A / Junctional Adhesion Molecule A Protein, Mouse, Recombinant (Fc Tag)

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JAM-A / Junctional Adhesion Molecule A Protein, Mouse, Recombinant (Fc Tag): 製品情報

純度
> 94 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the mouse F11R (NP_766235.1) extracellular domain (Met 1-Ala 242) was fused with the Fc region of human IgG1 at the C-terminus.
NP No.
発現ホスト
HEK293 Cells
Mouse
予測N末端
Lys 27
分子量
The secreted recombinant mouse F11R/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 457 amino acids and has a predicted molecular mass of 50.2 kDa. rmF11R/Fc monomer migrates as an is approximately 57 kDa band in SDS-PAGE under reducing conditions, with ~10% free Fc fragment.
バッファー
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

JAM-A / Junctional Adhesion Molecule A Protein, Mouse, Recombinant (Fc Tag): 画像

JAM-A / Junctional Adhesion Molecule A Protein, Mouse, Recombinant (Fc Tag): 別名

9130004G24 Protein, Mouse; AA638916 Protein, Mouse; ESTM33 Protein, Mouse; JAM Protein, Mouse; JAM-1 Protein, Mouse; JAM-A Protein, Mouse; Jcam Protein, Mouse; Jcam1 Protein, Mouse; Ly106 Protein, Mouse

JAM-A / Junctional Adhesion Molecule A 背景情報

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.
完全な名称
F11 receptor
参考文献
  • Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.
  • Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.
  • Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.
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