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IL2/IL-2/Interleukin-2  抗体

All IL2 Reagents

反応度: Human  
アプリケーション: ELISA  
11848-MM03-50
11848-MM03-200
11848-MM03-100
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    反応度: Human  
    アプリケーション: ELISA  
    11848-RP01-400
    11848-RP01-200
    11848-RP01-100
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      反応度: Human  
      アプリケーション: 
      11848-R062-50
      11848-R062-100
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        反応度: Mouse  
        アプリケーション: ELISA  WB  
        51061-T48-50
        51061-T48-200
        51061-T48-100
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        • Slide 1
        反応度: Mouse  
        アプリケーション: ELISA  
        51061-RP01-400
        51061-RP01-200
        51061-RP01-100
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        200 µg 
        100 µg 
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          反応度: Rat  
          アプリケーション: ELISA  
          80075-T16-50
          80075-T16-200
          80075-T16-100
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            反応度: Rat  
            アプリケーション: IHC-P  
            80075-MM10-50
            80075-MM10-200
            80075-MM10-100
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            反応度: Canine  
            アプリケーション: ELISA  
            70014-RP01-400
            70014-RP01-200
            70014-RP01-100
            400 µg 
            200 µg 
            100 µg 
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              反応度: Canine  
              アプリケーション: ELISA  WB  
              70014-T48-50
              70014-T48-200
              70014-T48-100
              50 µg 
              200 µg 
              100 µg 
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              • Slide 1
              反応度: Canine  
              アプリケーション: ELISA  
              70014-R001-50
              70014-R001-100
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              100 µg 
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                IL2/IL-2/Interleukin-2 関連製品

                IL2/IL-2/Interleukin-2 関連製品

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                IL2/IL-2/Interleukin-2 サマリー & タンパク質情報

                IL2/IL-2/Interleukin-2 関連情報

                IL2/IL-2/Interleukin-2 背景

                遺伝子の概要: The Interleukin 2 protein encoded by this IL2 gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this IL2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this IL2 gene in the immune response to antigenic stimuli.
                General information above from NCBI
                細胞内位置: Secreted.
                疾患関連性: DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
                シーケンスの類似性: Belongs to the IL-2 family. {ECO:0000305}.
                General information above from UniProt

                Interleukin-2, also known as T-cell growth factor, TCGF, Aldesleukin and IL2, is a secreted protein which belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced by macrophages, facilitates IL-2 production by T lymphocytes (T cells).
                Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2, and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy has been found to be ineffective.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                IL2/IL-2/Interleukin-2 代替名

                Interleukin-2, []
                IL2,IL-2,lymphokine,TCGF, [human]
                Il2,IL-2,TCGF,DN-144H19.3, [mouse]

                IL2/IL-2/Interleukin-2 関連研究

              • Smith KA, et al.,1980,  J. Exp. Med.151 (6): 1551-6. 
              • Smith KA, et al.,1980, Nature. 287 (5785): 853-5.
              • Taniguchi T, et al.,1983, Nature. 302 (5906): 305.
              • Cantrell DA, et al.,1984, Science. 224 (4655): 1312-6. 
              • Smith KA, et al.,1988, Science. 240 (4856): 1169-76.
              • Wang X. et al., 2005, Science 310:1159-63.
              • Stauber D.J. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 2788-93.
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