IL1R1 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All IL1R1 reagents are produced in house and quality controlled, including 23 IL1R1 Antibody, 5 IL1R1 ELISA, 52 IL1R1 Gene, 9 IL1R1 Lysate, 9 IL1R1 Protein, 3 IL1R1 qPCR. All IL1R1 reagents are ready to use.

IL1R1 Protein (9)

    IL1R1 Antibody (23)

      IL1R1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(5)

      IL1R1 cDNA Clone (52)

      NM_000877.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008362.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_013123.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001107510.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      IL1R1 Lysate (9)

        IL1R1 の背景知識

        Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

        IL1R1 の参考文献

        • Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.
        • Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.
        • Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.