Anti-IGFBP-6 Antibody

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Anti-IGFBP-6 Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-IGFBP-6 Antibody
検証済のアプリケーション
ELISA,IHC-P
交差反応
Reacts with: Mouse
特異性
Mouse IGFBP-6
免疫原
Recombinant Mouse IGFBP6 / IBP6 Protein (Catalog#50460-M08H)
調製
Produced in rabbits immunized with purified, recombinant Mouse IGFBP6 / IBP6 (rM IGFBP6 / IBP6; Catalog#50460-M08H; NP_032370.2; Met1-Gly238). IGFBP6 / IBP6 specific IgG was purified by Mouse IGFBP6 / IBP6 affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A & Antigen Affinity
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IGFBP-6 Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
IHC-P 1:100-1:500
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IGFBP-6 Antibody (Rabbit Polyclonal 抗体) の画像

Immunochemical staining of mouse IGFBP6 in mouse skeletal muscle with rabbit polyclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Anti-IGFBP-6 Antibody: 別名

Anti-IGFBP-6 Antibody

IGFBP-6 背景情報

Insulin-like growth factor binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are clearly distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF, or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.
完全な名称
insulin-like growth factor binding protein 6
参考文献
  • Denys H, et al. (2004) Identification of IGFBP-6 as a significantly downregulated gene by beta-catenin in desmoid tumors. Oncogene. 23(3): 654-64.
  • Bach LA. Insulin-like growth factor binding protein-6: the "forgotten" binding protein? Horm Metab Res. 31(2-3): 226-34.
  • Bach LA. IGFBP-6 five years on; not so 'forgotten'? Growth Horm IGF Res. 15(3): 185-92.
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