EphA4 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All EphA4 reagents are produced in house and quality controlled, including 5 EphA4 Antibody, 52 EphA4 Gene, 9 EphA4 Lysate, 9 EphA4 Protein, 3 EphA4 qPCR. All EphA4 reagents are ready to use.

EphA4 Protein (9)

    EphA4 Antibody (5)

      EphA4 cDNA Clone (52)

      NM_004438.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_007936.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001162411.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001106493.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      EphA4 Lysate (9)

        EphA4 関連の研究分野

        EphA4 の背景知識

        EPH receptor A4 (ephrin type-A receptor 4), also known as EphA4, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA1, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. EphA4 is enriched on dendritic spines of pyramidal neurons in the adult mouse hippocampus, and ephrin-A3 is localized on astrocytic processes that envelop spines. Eph receptor−mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). The extracellular domain of an EphA4 interacts with ephrin ligands, which may be tethered to neighbouring cells. Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer.

        EphA4 の参考文献

        • Murai KK, et al. (2003) Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci. 6(2): 153-60.
        • Kullander K, et al. (2003) Role of EphA4 and EphrinB3 in local neuronal circuits that control walking. Science. 299(5614): 1889-92.
        • Smith A, et al. (1997) The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells. Curr Biol. 7(8): 561-70.

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