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EMR2  Protein, Antibody, ELISA Kit, cDNA Clone

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EMR2 関連経路

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    EMR2 サマリー & タンパク質情報

    EMR2 背景

    サブユニット構造: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55. {ECO:0000269|PubMed:12829604, ECO:0000269|PubMed:15150276, ECO:0000269|PubMed:17449467}.
    ドメイン: The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.; Binding to chondroitin sulfate is mediated by the fourth EGF domain.
    細胞内位置: Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells.
    組織特異性: Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. {ECO:0000269|PubMed:10903844, ECO:0000269|PubMed:11994511}.
    翻訳後: Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit. {ECO:0000269|PubMed:12860403}.
    シーケンスの類似性: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. {ECO:0000305}.; Contains 5 EGF-like domains. {ECO:0000255|PROSITE-ProRule:PRU00076}.; Contains 1 GPS domain. {ECO:0000255|PROSITE-ProRule:PRU00098}.
    General information above from UniProt

    EMR2 代替名

    EMR2 関連研究