Anti-EGFR Antibody

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Anti-EGFR Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-EGFR Antibody
検証済のアプリケーション
ELISA,IHC-P
交差反応
Reacts with: Human
特異性
Human EGFR
免疫原
Recombinant Human EGFR / HER1 / ErbB1 Protein (Catalog#10001-H20B2)
調製
Produced in rabbits immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; Catalog#10001-H20B2; NP_005219; Met668-Ala1210). EGFR / HER1 / ErbB1 specific IgG was purified by Human EGFR / HER1 / ErbB1 affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A & Antigen Affinity
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-EGFR Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:5000-1:10000
IHC-P 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-EGFR Antibody (Rabbit Polyclonal 抗体) の画像

Immunochemical staining of human EGFR in human placenta with rabbit polyclonal antibody (1:1000,formalin-fixed paraffin embedded sections). Positive staining was localized to trophoblast.
Immunochemical staining of human EGFR in human ovarian cancer with rabbit polyclonal antibody (1:1000,formalin-fixed paraffin embedded sections).
Immunochemical staining of human EGFR in human colon carcinoma with rabbit polyclonal antibody (1:1000,formalin-fixed paraffin embedded sections).

Anti-EGFR Antibody: 別名

Anti-ERBB Antibody; Anti-ERBB1 Antibody; Anti-HER1 Antibody; Anti-mENA Antibody; Anti-NISBD2 Antibody; Anti-PIG61 Antibody

EGFR 背景情報

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
完全な名称
epidermal growth factor receptor
参考文献
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
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