Anti-CD59 Antibody (PerCP)

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Anti-CD59 Antibody (PerCP) (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-CD59 Antibody (PerCP)
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human CD59
免疫原
Recombinant Human CD59 Protein (Catalog#12474-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD59 (rh CD59; Catalog#12474-H08H; P13987-1; Met1-Glu101) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
ソース
Monoclonal Rabbit IgG Clone #029
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
標識物
PerCP
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD59 Antibody (PerCP) (Rabbit Monoclonal 抗体) の画像

Flow cytometric analysis of Human CD59 expression on human whole blood lymphocytes. Cells were stained with PerCP-conjugated anti-Human CD59. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.

Anti-CD59 Antibody (PerCP): 別名

Anti-16.3A5 Antibody; Anti-1F5 Antibody; Anti-EJ16 Antibody; Anti-EJ30 Antibody; Anti-EL32 Antibody; Anti-FLJ38134 Antibody; Anti-FLJ92039 Antibody; Anti-G344 Antibody; Anti-HRF-20 Antibody; Anti-HRF20 Antibody; Anti-MAC-IP Antibody; Anti-MACIF Antibody; Anti-MEM43 Antibody; Anti-MGC2354 Antibody; Anti-MIC11 Antibody; Anti-MIN1 Antibody; Anti-MIN2 Antibody; Anti-MIN3 Antibody; Anti-MIRL Antibody; Anti-MSK21 Antibody; Anti-p18-20 Antibody

CD59 背景情報

CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).
完全な名称
CD59 molecule
参考文献
  • Fletcher CM. et al., 1994, Structure. 2: 185-99.
  • Rudd PM. et al., 1997, J Biol Chem. 272: 7229-44.
  • Kimberley FC. et al., 2007, Mol Immunol. 44 (1-3): 73-81.
  • Gong Y. et al., 2007, Sci China C Life Sci. 50 (6): 773-9.
  • Picariello G. et al., 2008, Proteomics 8: 3833-47.
  • Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.

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