Anti-CD59 Antibody (PerCP)

CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

CD59 molecule

• Immunology>>Inflammation / Inflammatory Mediator>>Complement and Coagulation>>Complement Pathway
• Immunology>>Innate Immunity>>Complement System
• Cardiovascular>>Atherosclerosis>>Vascular Inflammation>>Innate and adaptive immunity
• Immunology>>Innate Immunity>>Complement System>>MAC
• Developmental Biology>>Embryogenesis>>Germ Layer Formation>>Mesoderm Marker
• Cancer>>Signal Transduction>>Protein Phosphorylation>>Tyrosine Kinase>>Other in Tyrosine Kinasse
• Stem Cells>>Hematopoietic Progenitors>>Surface Molecules of Hematopoietic Progenitors

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