Anti-CD33 Antibody (PerCP)

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Anti-CD33 Antibody (PerCP) (Mouse Monoclonal 抗体) の製品情報

製品名
Anti-CD33 Antibody (PerCP)
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human CD33
免疫原
Recombinant Human CD33 / Siglec-3 Protein (Catalog#12238-H08H)
調製
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD33 / Siglec-3 (rh CD33 / Siglec-3; Catalog#12238-H08H; AAH28152.1; Met1-His259) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
ソース
Monoclonal Mouse IgG1 Clone #09
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
標識物
PerCP
濃度
5 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD33 Antibody (PerCP) (Mouse Monoclonal 抗体) の画像

Flow cytometric analysis of Human CD33 expression on human whole blood monocytes. Cells were stained with PerCP-conjugated anti-Human CD33. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable monocytes.

Anti-CD33 Antibody (PerCP): 別名

Anti-p67 Antibody; Anti-Siglec-3 Antibody; Anti-SIGLEC3 Antibody

CD33 背景情報

Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33 /Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 /Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.
完全な名称
CD33 molecule
参考文献
  • Simmons D, et al. (1988) Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 141(8): 2797-800.
  • Ulyanova T, et al. (1999) The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 29(11): 3440-9.
  • Freeman SD, et al. (1995) Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 85(8): 2005-12.

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