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CD113/Nectin-3  抗体

All PVRL3 Reagents

反応度: Human  
アプリケーション: IHC-P  
10852-MM02-50
10852-MM02-200
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反応度: Human  
アプリケーション: ELISA  
10852-T16-50
10852-T16-200
10852-T16-100
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    反応度: Human  
    アプリケーション: ELISA  
    10852-RP01-400
    10852-RP01-200
    10852-RP01-100
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      反応度: Human  
      アプリケーション: ELISA  
      10852-MM04-50
      10852-MM04-200
      10852-MM04-100
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      200 µg 
      100 µg 
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        反応度: Human  
        アプリケーション: ELISA  WB  
        10852-RP02-50
        10852-RP02-200
        10852-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
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        CD113/Nectin-3 関連経路

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          CD113/Nectin-3 関連製品

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          CD113/Nectin-3 サマリー & タンパク質情報

          CD113/Nectin-3 背景

          遺伝子の概要: This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants
          General information above from NCBI
          サブユニット構造: Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between PVRL1 and PVRL3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with MLLT4/afadin, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT. {ECO:0000269|PubMed:11024295, ECO:0000269|PubMed:12759359, ECO:0000269|PubMed:16216929, ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:22902367}.
          細胞内位置: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
          組織特異性: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. {ECO:0000269|PubMed:11024295}.
          シーケンスの類似性: Belongs to the nectin family. {ECO:0000305}.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
          General information above from UniProt

          Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.

          CD113/Nectin-3 代替名

          CD113/Nectin-3 関連研究

        • Satoh-Horikawa, et al. (2000). Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem (UNITED STATES) . 275 (14): 10291-9.
        • Reymond N, et al. (2000). Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Gene (NETHERLANDS). 255 (2): 347-55.
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