Anti-Nectin-2 Antibody (PE)

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Anti-Nectin-2 Antibody (PE) (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-Nectin-2 Antibody (PE)
検証済のアプリケーション
FCM
交差反応
Reacts with: Human
特異性
Human Nectin-2
免疫原
Recombinant Human CD112 / Nectin-2 protein (Catalog#10005-H08H)
調製
This antibody was obtained from a rabbit immunized with purified, recombinant Human CD112 / Nectin-2 (rh CD112 / Nectin-2; Catalog#10005-H08H; NP_002847.1; Met1-Leu360) and conjugated with PE under optimum conditions, the unreacted PE was removed.
ソース
Monoclonal Rabbit IgG Clone #005
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.03%ProClin300
標識物
PE
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !

Anti-Nectin-2 Antibody (PE) (Rabbit Monoclonal 抗体) の画像

Flow cytometric analysis of anti-Human PVRL2(CD112) on A549 cells.

Anti-Nectin-2 Antibody (PE): 別名

Anti-CD112 Antibody; Anti-HVEB Antibody; Anti-Nectin-2 Antibody; Anti-PRR2 Antibody; Anti-PVRR2 Antibody

Nectin-2 背景情報

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.
完全な名称
poliovirus receptor-related 2 (herpesvirus entry mediator B)
参考文献
  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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