CaMKII alpha / CAMK2A (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All CaMKII alpha / CAMK2A reagents are produced in house and quality controlled, including 2 CaMKII alpha / CAMK2A Antibody, 30 CaMKII alpha / CAMK2A Gene, 1 CaMKII alpha / CAMK2A IP Kit, 1 CaMKII alpha / CAMK2A Lysate, 1 CaMKII alpha / CAMK2A Protein, 2 CaMKII alpha / CAMK2A qPCR. All CaMKII alpha / CAMK2A reagents are ready to use.

CaMKII alpha / CAMK2A の背景知識

Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII. It has been found to play a critical role in sustaining activation of CAMKII at the postsynaptic density. Studies have found that knockout mice without CAMKIIA demonstrate a low frequency of LTP. Additionally, these mice do not form persistent, stable place cells in the hippocampus.

CaMKII alpha / CAMK2A の参考文献

  • Lin CR, et al. (1987). Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. Proc Natl Acad Sci U S A. 84 (16): 5962-6.
  • Walikonis RS, et al. (2001) Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin. J Neurosci. 21 (2): 423-33.
  • Gardoni F, et al. (2003) CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J Biol Chem. 278 (45): 44745-52.