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B7-H4 / B7S1 / B7x 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

  • B7-H4 / B7S1 / B7x Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • B7-H4 / B7S1 / B7x Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • B7-H4 / B7S1 / B7x Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • B7-H4 / B7S1 / B7x Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
データシートレビュー関連製品プロトコル
人々 VTCN1 抗体製品情報
免疫原:Recombinant Human B7-H4 / B7S1 / B7x protein (Catalog#10738-H08H)
Clone ID:
Ig タイプ:Rabbit IgG
濃度:
エンドトキシン:
製剤:0.2 μm filtered solution in PBS
調製:Produced in rabbits immunized with purified, recombinant Human B7-H4 / B7S1 / B7x (rh B7-H4 / B7S1 / B7x; Catalog#10738-H08H; Q7Z7D3; Phe29-Ala258). B7-H4 / B7S1 / B7x specific IgG was purified by Human B7-H4 / B7S1 / B7x affinity chromatography.
人々 VTCN1 Antibody IHC Application Image
Other VTCN1 Antibody Products
Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
B7-H4/Vtcn1/B7S1 背景

V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type? membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

人々 B7-H4/Vtcn1/B7S1 参考文献
  • Zang X, et al. (2003) B7x: a widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci U S A. 100(18): 10388-92.
  • Suh WK, et al. (2006) Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol. 26(17): 6403-11.
  • Zang X, et al. (2007) B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci U S A. 104(49):19458-63.
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    カタログ: 10738-T24-100
    定価: 
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    Datasheet & Documentation

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