B7-1 Protein, Human, Recombinant (ECD, Fc Tag)

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B7-1 Protein, Human, Recombinant (ECD, Fc Tag): 製品情報

純度
> 95 % as determined by SDS-PAGE.
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
活性
Testing in progress
タンパク質の構築
A DNA sequence encoding the human CD80 (NP_005182.1) (Met1-Asn242) was expressed with the Fc region of human IgG1 at the C-terminus.
発現ホスト
HEK293 Cells
Human
予測N末端
Val 35
分子量
The recombinant human CD80 consists of 446 amino acids and predicts a molecular mass of 50.6 kDa.
バッファー
Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
配送
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
安定性 & 保存条件
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

B7-1 Protein, Human, Recombinant (ECD, Fc Tag): 画像

B7-1 Protein, Human, Recombinant (ECD, Fc Tag): 別名

B7 Protein, Human; B7-1 Protein, Human; B7.1 Protein, Human; BB1 Protein, Human; CD28LG Protein, Human; CD28LG1 Protein, Human; LAB7 Protein, Human

B7-1 背景情報

The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD8, is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. As costimulatory ligands, B7-1 which exists predominantly as dimer and the related protein B7-2, interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus constitute one of the dominant pathways that regulate T cell activation and tolerance, cytokine production, and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD8 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
完全な名称
CD80 molecule
参考文献
  • Greenfield EA, et al. (1998) CD28/B7 costimulation: a review. Crit Rev Immunol. 18(5): 389-418.
  • Zang X, et al. (2007) The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res. 13(18 Pt 1): 5271-9.
  • Mir MA, et al. (2008) Signaling through CD80: an approach for treating lymphomas. Expert Opin Ther Targets. 12(8): 969-79.
  • Immune Checkpoint Inhibitor-Induced Reinvigoration of Tumor-Infiltrating CD8+ T Cells is Determined by Their Differentiation Status in Glioblastoma
    Author
    Park, J;Kwon, M;Kim, KH;Kim, TS;Hong, SH;Kim, CG;Kang, SG;Moon, JH;Kim, EH;Park, SH;Chang, JH;Shin, EC;
    Year
    2019
    Journal
    Clin. Cancer Res.
    Application
    cell-based
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