Aspartate Aminotransferase (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All Aspartate Aminotransferase reagents are produced in house and quality controlled, including 1 Aspartate Aminotransferase Antibody, 75 Aspartate Aminotransferase Gene, 1 Aspartate Aminotransferase IP Kit, 1 Aspartate Aminotransferase Protein, 3 Aspartate Aminotransferase qPCR. All Aspartate Aminotransferase reagents are ready to use.

Aspartate Aminotransferase の背景知識

Aspartate aminotransferase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, aspartate aminotransferase and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. There is a rare in-frame deletion in aspartate aminotransferase gene, which inactivates cytosolic aspartate aminotransferase(cAST) enzyme in the Old Order Amish. This may help to understand structure and function of the enzyme and would be useful for predicting serum aspartate AST levels.

Aspartate Aminotransferase の参考文献

  • Shen H, et al. (2011) Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels. J Hum Genet. 56(11):801-5.
  • Doonan S, et al. (1985) Structural and genetic relationships between cytosolic and mitochondrial isoenzymes. Int J Biochem. 16(12):1193-9.
  • Panteghini M. (1990) Aspartate aminotransferase isoenzymes. Clin Biochem. 23(4):311-9.
  • Bousquet-Lemercier B, et al. (1990) Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection. Biochemistry. 29(22):5293-9.