Anti-Junctional Adhesion Molecule B / JAM2 Antibody

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Anti-Junctional Adhesion Molecule B / JAM2 Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-Junctional Adhesion Molecule B / JAM2 Antibody
検証済のアプリケーション
WB
交差反応
Reacts with: Human
特異性
Human Junctional Adhesion Molecule B / JAM2
免疫原
A synthetic peptide corresponding to the center region of the Human JAM2
調製
Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human JAM2, and purified by antigen affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A & Antigen Affinity
緩衝液
PBS, pH7.0 with 0.03% Proclin300
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Anti-Junctional Adhesion Molecule B / JAM2 Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
WB 1:500-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Junctional Adhesion Molecule B / JAM2 Antibody (Rabbit Polyclonal 抗体) の画像

Anti-JAM2 rabbit polyclonal antibody at 1:500 dilution

Lane A: HeLa Whole Cell Lysate

Lane B: A431 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:33 kDa

Observed band size:42 kDa

Anti-Junctional Adhesion Molecule B / JAM2 Antibody: 別名

Anti-C21orf43 Antibody; Anti-CD322 Antibody; Anti-JAM-B Antibody; Anti-JAMB Antibody; Anti-PRO245 Antibody; Anti-VE-JAM Antibody; Anti-VEJAM Antibody

Junctional Adhesion Molecule B / JAM2 背景情報

Junctional adhesion molecule B (JAM-B), also known as Junctional adhesion molecule 2 (JAM2), Vascular endothelial junction-associated molecule (VE-JAM), and CD322, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is prominently expressed on high endothelial venules. expression to be restricted to the high endothelial venule of tonsil and lymph nodes. The localization to the endothelium of arterioles in and around inflammatory and tumor foci. JAM-B can function as an adhesive ligand for the T cell line J45 and can interact with GM-CSF/IL-4-derived peripheral blood dendritic cells, circulating CD56(+) NK cells, circulating CD56(+)CD3(+) NK/T cells, and circulating CD56(+)CD3(+)CD8(+) cytolytic T cells. JAM-2 is expressed on high endothelial venules (HEVs) in human tonsil and on a subset of human leukocytes, suggesting that JAM-2 plays a central role in the regulation of transendothelial migration. It binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1. JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
完全な名称
junctional adhesion molecule 2
参考文献
  • Johnson-Lger CA, et al. (2002) Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood. 2100(7): 2479-86.
  • Liang TW, et al. (2002) Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. J Immunol. 168(4): 1618-26.
  • Ludwig RJ, et al. (2009) Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin. Immunology. 128(2): 196-205.

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