Anti-Cytokeratin 14 / KRT14 Antibody

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Anti-Cytokeratin 14 / KRT14 Antibody (Mouse Monoclonal 抗体) の製品情報

製品名
Anti-Cytokeratin 14 / KRT14 Antibody
検証済のアプリケーション
IHC-P
交差反応
Reacts with: Human
Predicted to React with: Mouse, Rat (Species predicted to react based on 100% sequence homology)
特異性
Human Cytokeratin 14 / KRT14
免疫原
A synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 14/KRT14
調製
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 14/KRT14. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
ソース
Monoclonal Clone #01
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Cytokeratin 14 / KRT14 Antibody (Mouse Monoclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
IHC-P 1:10000-1:20000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-Cytokeratin 14 / KRT14 Antibody (Mouse Monoclonal 抗体) の画像

Immunochemical staining of human KRT14 in human skin with mouse monoclonal antibody (1:20000, formalin-fixed paraffin embedded sections).
Immunochemical staining of human KRT14 in human esophageal carcinoma with mouse monoclonal antibody (1:20000, formalin-fixed paraffin embedded sections).

Anti-Cytokeratin 14 / KRT14 Antibody: 別名

Anti-CK14 Antibody; Anti-EBS3 Antibody; Anti-EBS4 Antibody; Anti-K14 Antibody; Anti-NFJ Antibody

Cytokeratin 14 / KRT14 背景情報

Cytokeratin 14, also known as Keratin 14 and K14, is a member of the keratin family. Cytokeratin 14 is a type I keratin. It is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Cytokeratin 14 is mainly expressed in the basal layer. It is also strongly expressed in the outer root sheath of anagen follicles. Cytokeratin 14 and keratin 5 may have a role in maintenance of cell proliferation potential in the basal layer of stratified epithelia, modulating phosphatidylinositol 3-kinase/Akt–mediated cell proliferation and/or Notch1-dependent cell differentiation. Cytokeratin 14 defect prevents it from working effectively with keratin 5 and interfering with the assembly of the keratin intermediate filament network. A disruption in this network makes keratinocytes fragile and prone to rupture. Minor trauma to the skin, such as rubbing or scratching, can cause these cells to break down, resulting in the formation of painful, fluid-filled blisters. Mutations in the K14 gene are also responsible for Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis.
完全な名称
keratin 14, type I
参考文献
  • Coulombe PA, et al., 1991, Cell. 66(6): 1301-11.
  • Schweizer J, et al., 2006, 174(2): 169-74.
  • Lugassy J, et al., 2006, Am J Hum Genet. 79(4): 724-30.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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