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アクチビン/インヒビン

Activin/Inhibin

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    アクチビン/インヒビン Background

    Activin and inhibin are members of the transforming growth factor-beta superfamily. Activin is a related dimeric protein composed of two ß subunits, ßA ßA (activin A), ßB ßB (activin B), or ßA ßB (activin AB).Inhibin is composed of an alpha and one of two ß subunits, ßA (inhibin A) or ßB (inhibin B). Activins are produced in many cell types and organs, whereas inhibin production is restricted mainly to the steroidogenic tissues and the hypophysis. Activins and inhibins are structurally related glycoprotein hormones modulating pituitary FSH secretion and gonadal steroidogenesis. Activins and inhibins are also produced in the adrenal cortex where their physiological role is poorly known. Both activins and inhibins have been suggested to be para/autocrine regulators of cell function.

    アクチビン/インヒビン References

      1. Yu J, et al. (1991) Specific roles of activin/inhibin in human erythropoiesis in vitro. Ann N Y Acad Sci. 628:199-211.
      2. Wu T, et al. (2000) Activin, inhibin, and follistatin in zebrafish ovary: expression and role in oocyte maturation. Biol Reprod. 62(6):1585-92.
      3. Reis FM, et al. (2004) Activin, inhibin and the human breast. Mol Cell Endocrinol. 225(1-2):77-82.
      4. Bertram R, et al. (2008) A mathematical model for the actions of activin, inhibin, and follistatin on pituitary gonadotrophs. Bull Math Biol. 70(8):2211-28.