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    ABI2 サマリー & タンパク質情報

    ABI2 背景

    サブユニット構造: Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Interacts with ABL1 and ABL2. {ECO:0000250, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}.
    細胞内位置: Cytoplasm {ECO:0000250}.; Isoform 1: Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Isoform 1 but not isoform 3 is localized to protruding lamellipodia and filopodia tips. {ECO:0000250}.
    翻訳後: Is a substrate for ABL1.
    シーケンスの類似性: Belongs to the ABI family. {ECO:0000305}.; Contains 1 SH3 domain. {ECO:0000255|PROSITE-ProRule:PRU00192}.; Contains 1 t-SNARE coiled-coil homology domain. {ECO:0000255|PROSITE-ProRule:PRU00202}.
    General information above from UniProt

    ABI2 代替名

    ABI-2,ABI2B,AIP-1,AblBP3,argBP1,SSH3BP2,argBPIA,argBPIB, [homo-sapiens]
    AI839867,C130078H13,8430425M24Rik, [mus-musculus]

    ABI2 関連研究