ABHD1: ABHD1 Protein | ABHD1 Antibody

ABHD1 Gene family

ABHD1 Background

Alpha/beta hydrolase domain containing gene 1 (ABHD1) is a member of the AB hydrolase superfamily and encodes a protein with an alpha/beta hydrolase fold. This domain is common to a number of hydrolytic enzymes of widely differing phylogenetic origins and catalytic functions. .The nine exon human ABHD1 gene is located on chromosome 2p23.3 and encodes a 45-residue protein containing a catalytic triad analogous to that present in serine proteases.ABHD1 was expressed in all tissues and cells examined, but levels of ABHD1 varied greatly, being high in skeletal muscle and testis and low in spleen and fibroblasts.

Reference for ABHD1

  • Edgar AJ (2003) The gene structure and expression of human abhd1: Overlapping polyadenylation signal sequence with sec12. BMC Genomics 4(1), 18.

ABHD1 Protein

ABHD1 protein expression

Tissue specificity

Ubiquitously expressed.

ABHD1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    405.00
  • Mass (Da)
    45.00

ABHD1 Antibody

There are 1 ABHD1 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 ABHD1 antibody for IHC-P. Among all these ABHD1 antibodies, there are 1 anti-ABHD1 rabbit polyclonal antibodies . All the ABHD1 anbodies are produced in house and all are in stock. ABHD1 antibody customerized service is available.

ABHD1 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]