ABCF3: ABCF3 Protein | ABCF3 Antibody

ABCF3 Gene family

ABCF3 Protein

ABCF3 protein function

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.

ABCF3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    709.00
  • Mass (Da)
    79.00

ABCF3 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]