ABCD4: ABCD4 Protein | ABCD4 Antibody

ABCD4 Gene family

ABCD4 Protein

ABCD4 protein function

May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm.

ABCD4 protein expression

Tissue specificity

Ubiquitous.

ABCD4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    606.00
  • Mass (Da)
    68.00

ABCD4 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]