ABCB5: ABCB5 Protein | ABCB5 Antibody

ABCB5 Gene family

ABCB5 Protein

ABCB5 protein function

Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair. {ECO:0000269|PubMed:12960149, ECO:0000269|PubMed:15205344, ECO:0000269|PubMed:15899824, ECO:0000269|PubMed:22306008}.

ABCB5 protein expression

Tissue specificity

Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.

ABCB5 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,257.00
  • Mass (Da)
    138.00

ABCB5 Antibody

There are 1 ABCB5 antibodies which are validated in multiple tissues with various applications, including WB. There are 1 ABCB5 antibody for WB. Among all these ABCB5 antibodies, there are 1 anti-ABCB5 rabbit polyclonal antibodies . All the ABCB5 anbodies are produced in house and all are in stock. ABCB5 antibody customerized service is available.

ABCB5 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]