ABCA3: ABCA3 Protein | ABCA3 Antibody

ABCA3 Gene family

ABCA3 Protein

ABCA3 protein function

Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol.

ABCA3 protein expression

Tissue specificity

Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma.

ABCA3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,704.00
  • Mass (Da)
    191.00

ABCA3 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]