AARSD1: AARSD1 Protein | AARSD1 Antibody

AARSD1 Background

AARSD1 belongs to the class-II aminoacyl-tRNA synthetase family, Alax-L subfamily. AARSD1 binds 1 zinc ion per subunit functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). Four transcript variants have been described for AARSD1: NM_25267.3, NM_113642.2, NM_1142653.1 and NM_1142654.1. It has been determined that the latter two variants represent a distinct upstream locus, which is now represented by GeneID:1885848 (PTGES3L), while the former two variants represent readthrough transcripts between PTGES3L and this locus (AARSD1). The readthrough locus (PTGES3L-AARSD1) is now represented by GeneID:188585.

Reference for AARSD1

  • Tatham MH, et al. (2011) Comparative proteomic analysis identifies a role for SUMO in protein quality control. Oncogene. 19(17):2120-8.
  • Kim W, et al. (2011) Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 44(2):325-40.
  • Udeshi ND, et al. (2012) Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Mol Cell Proteomics. 11(5):148-59.

AARSD1 Protein

AARSD1 protein function

Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). {ECO:0000250}.

AARSD1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    412.00
  • Mass (Da)
    45.00

AARSD1 Antibody

There are 4 AARSD1 antibodies which are validated in multiple tissues with various applications, including ELISA, WB, ICC/IF, IF, IP. There are 4 AARSD1 antibody for ELISA, 2 AARSD1 antibody for WB, 1 AARSD1 antibody for ICC/IF, 1 AARSD1 antibody for IF, 1 AARSD1 antibody for IP. Among all these AARSD1 antibodies, there are 1 anti-AARSD1 mouse monoclonal antibodies , 1 anti-AARSD1 rabbit monoclonal antibodies , 2 anti-AARSD1 rabbit polyclonal antibodies . All the AARSD1 anbodies are produced in house and all are in stock. AARSD1 antibody customerized service is available.

AARSD1 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]