Aminoadipate aminotransferase: Aminoadipate aminotransferase Protein | Aminoadipate aminotransferase Antibody

Aminoadipate aminotransferase Protein

Aminoadipate aminotransferase protein function

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

Aminoadipate aminotransferase protein expression

Tissue specificity

Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.

Aminoadipate aminotransferase protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    425.00
  • Mass (Da)
    47.00

Aminoadipate aminotransferase Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]