AADAC/arylacetamide deacetylase: AADAC/arylacetamide deacetylase Protein | AADAC/arylacetamide deacetylase Antibody

AADAC/arylacetamide deacetylase Gene family

AADAC/arylacetamide deacetylase Protein

AADAC/arylacetamide deacetylase protein function

Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity. {ECO:0000269|PubMed:17936933, ECO:0000269|PubMed:19339378, ECO:0000269|PubMed:22207054, ECO:0000269|PubMed:22415931, ECO:0000269|PubMed:23542347}.

AADAC/arylacetamide deacetylase protein expression

Tissue specificity

Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.

Induction

Down-regulated following infection with hepatis C virus which results in impaired triacylglycerol lipolysis and impaired assembly of very low density lipoproteins. This may represent a cellular adaptation to infection that is aimed at limiting viral production.

AADAC/arylacetamide deacetylase protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    399.00
  • Mass (Da)
    45.00

AADAC/arylacetamide deacetylase Antibody

There are 1 AADAC/arylacetamide deacetylase antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 AADAC/arylacetamide deacetylase antibody for IHC-P. Among all these AADAC/arylacetamide deacetylase antibodies, there are 1 anti-AADAC/arylacetamide deacetylase rabbit polyclonal antibodies . All the AADAC/arylacetamide deacetylase anbodies are produced in house and all are in stock. AADAC/arylacetamide deacetylase antibody customerized service is available.

AADAC/arylacetamide deacetylase Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]