Anti-2B4 / CD244 Antibody

The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of the signaling lymphocyte activation molecule (SLAM)-related receptor family and is important for stimulating NK cell cytotoxicity and cytokine production, which is expressed on all NK cells, a subpopulation of T cells, monocytes and basophils. The 2B4 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 can effectively activate and enhance NK cell–mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a cell surface glycoprotein of the Ig-superfamily structurally related to CD2-like molecules such as CD2, CD48, CD58, CD84, Ly-9, and SLAM, 2B4 (CD244) is expressed on all human NK cells, a subpopulation of T cells, basophils and monocytes. 2B4 activates NK cell mediated cytotoxicity, induces secretion of IFN-gamma and matrix metalloproteinases, and NK cell invasiveness.

• Cancer Immunotherapy
• Co-inhibitory Immune Checkpoint Targets
• Immune Checkpoint
• Immune Checkpoint Detection: Antibodies
• Immune Checkpoint Detection: ELISA Antibodies
• Immune Checkpoint Detection: FCM Antibodies
• Immune Checkpoint Detection: IP Antibodies
• Immune Checkpoint Proteins
• Immune Checkpoint Targets
• Immunotherapy
• Targeted Therapy

CD244 molecule, natural killer cell receptor 2B4

• Immunology>>Cluster of Differentiation (CD)>>Granulocyte CD Antigen>>CD Antigen (Basophils)
• Immune Checkpoint>>Co-inhibitory Immune Checkpoint
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Co-stimulatory Molecules
• Cancer>>Signal Transduction>>ITIM/ITAM Immunoreceptors and Related Molecules
• Immunology>>Cluster of Differentiation (CD)>>Monocyte/Macrophage CD Antigen>>Monocyte Marker CD Antigen
• Immunology>>Innate Immunity>>Monocytes/Macrophages>>Monocyte Markers
• Immunology>>Cluster of Differentiation (CD)>>Natural Killer (NK) Cell CD Antigen
• Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)
• Stem Cells>>Hematopoietic Progenitors>>Lymphoid>>NK Cell Lineage
• Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>SLAM Family
• Stem Cells>>Hematopoietic Progenitors>>Lymphoid>>T Lymphocytic Lineage

• Nakajima H, et al. (2000) 2B4: an NK cell activating receptor with unique specificity and signal transduction mechanism. Hum Immunol. 61(1): 39-43.
• Chuang SS, et al. (2001) 2B4 (CD244)-mediated activation of cytotoxicity and IFN-gamma release in human NK cells involves distinct pathways. J Immunol. 167(11): 6210-6.
• McNerney ME, et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol Immunol. 42(4): 489-94.
• Mathew SO, et al. (2009) Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 39(6): 1632-41.