14-3-3 eta / YWHAH cDNA ORF Clone in Cloning Vector, Human

YWHAH, the gene encoding the 14-3-3eta isoform, is highly expressed in retinal ganglion cells (RGC). YWHAH is a positional and functional candidate gene for both schizophrenia and bipolar disorder (BP). It is located on chromosome 22q12.3, a region which has been implicated by linkage studies in both BP and schizophrenia.

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

• Cancer>>Signal Transduction>>Adaptor Proteins
• Cancer>>Signal Transduction>>Akt Pathway>>Adaptor Proteins in the Akt Pathway
• Cancer>>Signal Transduction>>Signaling Pathway>>Representative pathway>>Apoptosis Signaling pathway>>Apoptosis Adaptor Proteins
• Cancer>>Signal Transduction>>Signaling Pathway>>Representative pathway>>Apoptosis Signaling pathway>>Bcl-2 Proteins and Regulators
• Neuroscience>>Neurotransmission>>Intracellular Signaling>>Adapters>>Cytoplasmic
• Cancer>>Signal Transduction>>phospho-Serine/phospho-Threonine Binding Proteins

• Wakui H, et al. (1997) Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein. J Biol Chem. 272(13): 8153-6.
• Toyooka K, et al. (2002) Isolation and structure of the mouse 14-3-3 eta chain gene and the distribution of 14-3-3 eta mRNA in the mouse brain. Brain Res Mol Brain Res. 100(1-2): 13-20.
• Kim YS, et al. (2005) Role of 14-3-3 eta as a positive regulator of the glucocorticoid receptor transcriptional activation. Endocrinology. 146(7): 3133-40.
• Grover D, et al. (2009) Family-based association of YWHAH in psychotic bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 150B(7): 977-83.