14-3-3 beta (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All 14-3-3 beta reagents are produced in house and quality controlled, including 9 14-3-3 beta Antibody, 62 14-3-3 beta Gene, 3 14-3-3 beta IP Kit, 3 14-3-3 beta Protein, 2 14-3-3 beta qPCR. All 14-3-3 beta reagents are ready to use.

14-3-3 beta Protein (3)

14-3-3 beta Antibody (9)

14-3-3 beta cDNA Clone (62)

NM_003404.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_018753.6

クローニングベクター cDNA 製品

In lentiviral vector

NM_019377.1

クローニングベクター cDNA 製品

In lentiviral vector

XM_001109676.2

クローニングベクター cDNA 製品

In lentiviral vector

XM_002721227.1

クローニングベクター cDNA 製品

In lentiviral vector

14-3-3 beta の背景知識

14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 1% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

14-3-3 beta の参考文献

  • Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.
  • Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.
  • Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.